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Thirdly, advance the development of novel saponin formulations (e.g., nanoparticle-encapsulated, receptor-targeted liposomes, pH-responsive prodrugs) and initiate phase I/II clinical trials combining these optimized formulations with standard chemotherapeutic regimens, focusing on evaluating their in vivo bioavailability, safety profiles (especially hemolytic toxicity and organ tolerance), and clinical efficacy in cancer patients, while establishing unified evaluation criteria for the therapeutic potential of saponin-based combination therapies

[21] [22] Epitalon and epithalamin appear to restore melatonin secretion by the pineal gland [3] in both aged monkeys and humans

Berenbaum MR, Johnson RM

--- Who Benefits Most Adults 30 and Over GH production declines progressively after age 30

Unadjusted model adjust for none